diff --git a/python/tox.ini b/python/tox.ini
index 99fd0c703..a68b4e729 100644
--- a/python/tox.ini
+++ b/python/tox.ini
@@ -25,6 +25,9 @@ deps =
     pytest-xdist
     pdbpp
     requests
+# urllib3 2.0 does not work in manylinux2014 containers.
+# https://github.com/deltachat/deltachat-core-rust/issues/4788
+    urllib3<2
 
 [testenv:.pkg]
 passenv =